On October 18, 1999 the Southern Nevada Health District , Office of Epidemiology implemented an Influenza Surveillance Program. The primary objective of the program was to monitor influenza-like illness (ILI), which is defined as a patient with fever >100°F (37.8° C) and cough or sore throat.

In response to the novel H1N1 outbreak in the Spring of 2009, the Southern Nevada Health District created the Enhanced Pediatric Influenza Surveillance (EPIS) project in June 2009. The EPIS project was supported by staff from the Office of Epidemiology and the Southern Nevada Public Health Laboratory and four pediatric clinics in Las Vegas. The goal of EPIS was to monitor what type of influenza viruses are circulating in the community.

The Influenza Surveillance and Enhanced Pediatric Influenza Surveillance programs are now part of the Pediatric Early Warning Sentinel Surveillance program.